منابع مشابه
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase catalyzes a complex rearrangement of 5-aminoimidazole ribonucleotide (AIR) to form HMP-P, the pyrimidine moiety of thiamine phosphate. We determined the three-dimensional structures of HMP-P synthase and its complexes with the product HMP-P and a substrate analog imidazole ribotide. The structure of HMP-P synthase reveals a h...
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The human genome encodes 57 cytochrome P450 genes, whose enzyme products metabolize hundreds of drugs, thousands of xenobiotics, and unknown numbers of endogenous compounds, including steroids, retinoids, and eicosanoids. Indeed, P450 genes are the first line of defense against daily environmental chemical challenges in a manner that parallels the immune system. Several National Institutes of H...
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Vorapaxar is the first substance of a new class of antiplatelet drugs that has been tested in large clinical trials. The protease-activated receptor 1 (PAR-1) antagonist inhibits thrombin-induced platelet activation to prevent atherothrombosis. In the phase 3 trials TRACER (acute coronary syndrome) and TRA 2P-TIMI 50 (stable atherosclerosis) reducing ischemic events with vorapaxar came at the c...
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Scientists and engineers can exploit nanostructures to manipulate thermal transport in solids. This is possible because the dominant heat carriers in nonmetals – crystal vibrations (or phonons) – have characteristic lengths in the nanometer range. We review research where this approach is used and propose future research directions. For instance, concepts such as phonon filtering, correlated sc...
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On this paper, the electronic system and oceanographic instruments of a moored buoy are presented. The system has been designed by the SARTI research team to meet a very specific objective, which is to expand the capabilities of the underwater observatory OBSEA as a research and test platform, providing an infrastructure for testing instruments either at the seafloor or at the surface. The syst...
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ژورنال
عنوان ژورنال: Nature
سال: 1989
ISSN: 0028-0836,1476-4687
DOI: 10.1038/337514a0